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KMID : 0387719950060020169
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Korean Journal of Blood Transfusion
1995 Volume.6 No. 2 p.169 ~ p.175
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Stem Cell Supportive Care in Chemotherapy of Acute Leukemia
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이규보
배선근/손상균/이재태/이건수/이경혜/서장수
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Abstract
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Object:
Peripheral blood stem cells(PBSC) were collected after remission induction chemotherapy and reinfused after intensified chemotherapy in order to increase the chemotherapeutic efficacy.
Method:
Collection of mononuclear cells(MNC) was started when CD34+ cells above 1% and WBC above 1,000/ul with mononuclear cell percentage above 30%, the collection procedures were done 2-6 times in each patient of total 6 cases. The collected MNCs
were
stored in -75℃ and reinfused after thawing in the water bath at 37℃.
Results:
Twenty three collection procedures from the 6 cases of acute leukemia had made effective MNC collection in 4 cases and mean collection efficiency was 49.8%(from 39.0% to 74.5%). Hematological changes after the procedure were mean reduction of
hemoglobin 1.34g/dl and mean 20.25% of decreased platelet count. There were noticcd transient symptoms of discomfort, coughing, chest tightness and dyspnea in association with the infusion of stored cells.
Conclusion:
The basic process for the peripheral blood stem cell transplantation(PBSCT) was accomplished with this supportive care for the consolidation chemotherapy of acute leukemia. Effective PBSCT would be warrented with more qualified process and high
dose
chemotherapy.
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KEYWORD
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